Synthesis of 1,2,3- Triazole Nucleoside Analogues
نویسندگان
چکیده
Both 1,2,3-triazoles and nucleosides have proved to be useful pharmacophores for antiviral and anticancer agents. A series of novel 1,2,3-triazole nucleoside analogues were designed and synthesized in order to find new antiviral or antitumor compounds. KEYWORD: Triazole; Nucleoside; Virus; Cancer International Conference on Industrial Technology and Management Science (ITMS 2015) © 2015. The authors Published by Atlantis Press 1090 Scheme 1 Reagents and conditions: i) 2-Butyne-1,4-diol, tolune, 110 o C, 90%; ii) TrCl, Et3N, CH2Cl2, 0 o C, 85%; iii) MsCl, Et3N, CH2Cl2, 0 o C, 90%; iv) 6-chloro-purine, K2CO3, DMF, rt, 60%; v) 6-Chloroguanine, K2CO3, DMF, rt, 65%; vi) CF3COOH, CH2Cl2, rt, 75%; vii) a) CH3NH2/EtOH, 60 o C, 65%; b) NH3 H2O/EtOH, 60 o C, 74%; c) cyclopropylamine, EtOH, 60 o C, 70%; d) MeONa, MeOH, 60 o C, 75%; e) EtONa, EtOH, 60 o C, 80%; ix) CF3COOH, reflux, 70%.
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